The present research is devoted revealing of interrelations of genetic markers interleukines with clinical signs chronic glomerulonephritis.It is established that a marker of development of mixed type chronic glomerulonephritis at a Hand Axes disease aggravation are genotypes 4R/4R a gene of the antagonist of a receptor interleukin 1 and -592AA, -592AS gene IL-10.The positive association of genotypes 2R/5R, 4R/5R IL-1Ra with type chronic glomerulonephritis in a disease Electrical current is revealed.